.ic-container {
    width: 100%;
    max-width: 1180px;
    margin-right: auto;
    margin-left: auto;
    padding-top: 25px;
    padding-bottom: 55px;
}

.ic-container p,
.ic-container li {
    line-height: 1.45;
}

.ic-container sup {
    position: relative;
    top: -0.2em;
    font-size: 55%;
    line-height: 0;
}

/* =========================================================
   MARCAS
   ========================================================= */

.ic-marcas {
    display: flex;
    justify-content: space-between;
    align-items: center;
    width: 100%;
    min-height: 105px;
    margin-bottom: 55px;
    padding: 10px 20px 18px;
    border-bottom: 1px solid #d6d6d6;
}

.ic-marca {
    display: flex;
    justify-content: center;
    align-items: center;
}

.ic-marca img {
    display: block;
    max-width: 100%;
    height: auto;
    object-fit: contain;
}

.ic-marca-novartis {
    width: 235px;
}

.ic-marca-novartis img {
    width: 100%;
    max-height: 70px;
}

.ic-marca-vms {
    width: 105px;
}

.ic-marca-vms img {
    width: 100%;
    max-height: 90px;
}

/* =========================================================
   CABEÇALHO
   ========================================================= */

.ic-cabecalho {
    margin-bottom: 40px;
}

.ic-cabecalho h1 {
    max-width: 850px;
    margin: 0 0 12px;
    color: #111;
    font-size: 38px;
    font-weight: 700;
    line-height: 1.12;
    text-align: left;
}

.ic-cabecalho p {
    margin: 0;
    color: #333;
    font-size: 19px;
    line-height: 1.3;
}

/* =========================================================
   BANNER
   ========================================================= */

.ic-banner-conteudo {
    width: 100%;
    margin: 0 auto 48px;
    overflow: hidden;
    border-radius: 24px;
    text-align: center;
}

.ic-banner-conteudo img {
    display: block;
    width: 100%;
    max-width: 100%;
    height: auto;
}

@media (min-width: 992px) {
    .ic-banner-conteudo img {
        width: 90%;
        margin: 0 auto;
    }
}

/* =========================================================
   TEXTOS
   ========================================================= */

.ic-texto-introducao {
    margin-bottom: 40px;
}

.ic-texto-introducao p {
    margin-bottom: 18px;
}

.ic-texto-introducao p:last-child {
    margin-bottom: 0;
}

.ic-secao {
    width: 100%;
    /* padding: 50px 0px */
}

.ic-titulo-secao {
    margin: 0 0 4px;
    color: #c90000;
    font-size: 26px;
    font-weight: 700;
    line-height: 1.2;
    text-transform: uppercase;
}

.ic-titulo-secao sup {
    font-size: 50%;
}

.ic-texto-apoio {
    margin-top: 0;
    margin-bottom: 0;
}

/* =========================================================
   SINTOMAS
   ========================================================= */

.ic-sintomas {
    display: flex;
    justify-content: space-between;
    align-items: flex-end;
    gap: 25px;
    width: 100%;
    margin: -10px auto 70px;
    padding: 0 30px;
}

.ic-sintoma {
    display: flex;
    flex: 1 1 0;
    justify-content: center;
    align-items: flex-end;
    width: calc((100% - 50px) / 3);
    min-width: 0;
    height: 500px;
    overflow: visible;
    text-align: center;
}

.ic-sintoma img {
    display: block;
    width: 85%;
    height: 85%;
    max-width: 330px;
    object-fit: contain;
    object-position: center bottom;
}

.ic-sintoma-terceiro img {
    transform: scale(1.04);
    transform-origin: center bottom;
}

/* =========================================================
   PERFIL DO PACIENTE
   ========================================================= */

.ic-perfil {
    display: grid;
    grid-template-columns: minmax(300px, 390px) minmax(0, 1fr);
    align-items: center;
    gap: 55px;
    width: 100%;
    margin: 5px 0 20px;
}

.ic-hospitalizacao {
    display: flex;
    align-items: center;
    min-height: 235px;
    padding: 38px 36px;
    border-radius: 22px;
    background-color: #c90000;
    color: #fff;
}

.ic-hospitalizacao p {
    margin: 0;
    color: #fff;
    font-size: 27px;
    font-weight: 700;
    line-height: 1.12;
}

.ic-perfil-conteudo {
    display: grid;
    grid-template-columns: 180px minmax(0, 1fr);
    align-items: center;
    gap: 32px;
    min-width: 0;
}

.ic-perfil-imagem {
    display: flex;
    justify-content: center;
    align-items: center;
    width: 180px;
    min-height: 185px;
    text-align: center;
}

.ic-perfil-imagem img {
    display: block;
    width: 85%;
    max-width: 180px;
    max-height: 185px;
    height: auto;
    object-fit: contain;
}

.ic-perfil-texto {
    min-width: 0;
}

.ic-perfil-texto h2 {
    margin: 0 0 2px;
    color: #111;
    font-size: 25px;
    font-weight: 700;
    line-height: 1.2;
    text-transform: uppercase;
}

.ic-perfil-texto .ic-subtitulo {
    margin: 0 0 14px;
    color: #c90000;
    font-size: 18px;
    font-weight: 700;
    line-height: 1.25;
}

.ic-perfil-texto ul {
    margin: 0;
    padding-left: 22px;
}

.ic-perfil-texto li {
    margin-bottom: 3px;
}

.ic-perfil-texto li::marker {
    color: #c90000;
}

/* =========================================================
   TRATAMENTO
   ========================================================= */

.ic-secao-tratamento {
    margin-top: 0;
    padding: 50px 0px
}

.ic-secao-tratamento > p {
    margin-top: 7px;
    margin-bottom: 0;
}

.ic-tratamentos {
    display: grid;
    grid-template-columns: repeat(3, minmax(0, 1fr));
    align-items: stretch;
    justify-content: center;
    gap: 24px;
    width: 100%;
    max-width: 860px;
    margin: 38px auto 48px;
}

.ic-tratamento-card {
    display: flex;
    justify-content: center;
    align-items: stretch;
    width: 100%;
    min-width: 0;
}

.ic-tratamento-card img {
    display: block;
    width: 85%;
    max-width: 85%;
    height: auto;
    object-fit: contain;
}

/* =========================================================
   DOWNLOAD
   ========================================================= */

.ic-download {
    text-align: center;
    margin-bottom: 70px
}

.ic-download p {
    margin: 0 0 22px;
    font-size: 21px;
    line-height: 1.3;
}

.ic-download p strong {
    color: #c90000;
}

.ic-download-botao {
    display: inline-flex;
    justify-content: center;
    align-items: center;
    min-width: 290px;
    min-height: 58px;
    padding: 12px 38px;
    border-radius: 32px;
    background-color: #c90000;
    color: #fff !important;
    font-size: 21px;
    font-weight: 700;
    line-height: 1;
    text-decoration: none !important;
    transition:
        opacity 0.2s ease,
        transform 0.2s ease;
}

.ic-download-botao:hover,
.ic-download-botao:focus {
    outline: none;
    color: #fff !important;
    opacity: 0.9;
    transform: translateY(-1px);
}

/* =========================================================
   REFERÊNCIAS
   ========================================================= */

.ic-referencias {
    margin-bottom: 10px;
    padding: 20px 22px;
    overflow-wrap: anywhere;
    word-break: normal;
}

.ic-referencias-titulo {
    margin-bottom: 8px !important;
}

.ic-referencias p {
    margin-top: 0;
    margin-bottom: 6px;
    font-size: 12px;
    line-height: 1.35;
}

.ic-referencias a {
    overflow-wrap: anywhere;
    word-break: break-word;
}

/* =========================================================
   TABLET
   ========================================================= */

@media (max-width: 991px) {
    .ic-container {
        padding-top: 20px;
    }

    .ic-marcas {
        min-height: 95px;
        margin-bottom: 45px;
    }

    .ic-marca-novartis {
        width: 205px;
    }

    .ic-marca-vms {
        width: 92px;
    }

    .ic-cabecalho h1 {
        font-size: 34px;
    }

    .ic-cabecalho p {
        font-size: 18px;
    }

    .ic-banner-conteudo {
        margin-bottom: 40px;
        border-radius: 20px;
    }

    .ic-sintomas {
        gap: 18px;
        padding-right: 10px;
        padding-left: 10px;
    }

    .ic-sintoma {
        height: 420px;
    }

    .ic-perfil {
        grid-template-columns: minmax(260px, 330px) minmax(0, 1fr);
        gap: 30px;
    }

    .ic-hospitalizacao {
        min-height: 210px;
        padding: 30px;
    }

    .ic-hospitalizacao p {
        font-size: 23px;
    }

    .ic-perfil-conteudo {
        grid-template-columns: 130px minmax(0, 1fr);
        gap: 20px;
    }

    .ic-perfil-imagem {
        width: 130px;
        min-height: 150px;
    }

    .ic-perfil-imagem img {
        width: 100%;
        max-width: 130px;
        max-height: 150px;
    }

    .ic-perfil-texto h2 {
        font-size: 21px;
    }

    .ic-perfil-texto .ic-subtitulo {
        font-size: 16px;
    }

    .ic-download {
        margin-top:0px;
        margin-bottom: 70px;
        text-align: center;
    }
}

/* =========================================================
   MOBILE
   ========================================================= */

@media (max-width: 767px) {
    .ic-container {
        padding-right: 15px;
        padding-left: 15px;
        padding-bottom: 45px;
    }

    .ic-marcas {
        min-height: 75px;
        margin-bottom: 35px;
        padding: 5px 2px 14px;
    }

    .ic-marca-novartis {
        width: 160px;
    }

    .ic-marca-novartis img {
        max-height: 52px;
    }

    .ic-marca-vms {
        width: 72px;
    }

    .ic-marca-vms img {
        max-height: 64px;
    }

    .ic-cabecalho {
        margin-bottom: 30px;
    }

    .ic-cabecalho h1 {
        margin-bottom: 10px;
        font-size: 28px;
        line-height: 1.15;
    }

    .ic-cabecalho p {
        font-size: 17px;
    }

    .ic-banner-conteudo {
        margin-bottom: 35px;
        border-radius: 16px;
    }

    .ic-texto-introducao {
        margin-bottom: 35px;
    }

    .ic-titulo-secao {
        font-size: 23px;
    }

    .ic-sintomas {
        flex-direction: column;
        justify-content: flex-start;
        align-items: center;
        gap: 55px;
        margin-top: 35px;
        margin-bottom: 55px;
        padding: 0;
    }

    .ic-sintoma {
        display: flex;
        flex: none;
        justify-content: center;
        align-items: center;
        width: 100%;
        max-width: 280px;
        height: auto;
        min-height: 0;
        overflow: visible;
    }

    .ic-sintoma img {
        display: block;
        width: 100%;
        max-width: 220px;
        height: auto;
        object-fit: contain;
        object-position: center;
        transform: none;
    }

    .ic-sintoma-terceiro {
        max-width: 260px;
        margin-top: 10px;
    }

    .ic-sintoma-terceiro img {
        width: 100%;
        max-width: 260px;
        height: auto;
        transform: none;
    }

    .ic-perfil {
        display: flex;
        flex-direction: column;
        align-items: stretch;
        gap: 35px;
    }

    .ic-hospitalizacao {
        width: 100%;
        min-height: auto;
        padding: 28px;
        border-radius: 18px;
    }

    .ic-hospitalizacao p {
        font-size: 23px;
    }

    .ic-perfil-conteudo {
        display: flex;
        flex-direction: column;
        align-items: center;
        gap: 22px;
        width: 100%;
    }

    .ic-perfil-imagem {
        flex: 0 0 120px;
        width: 120px;
        min-height: 140px;
    }

    .ic-perfil-imagem img {
        max-width: 120px;
        max-height: 140px;
    }

    .ic-perfil-texto {
        flex: 1;
        text-align: left;
    }

    .ic-perfil-texto h2 {
        font-size: 21px;
    }

    .ic-perfil-texto ul {
        padding-left: 20px;
    }

    .ic-tratamentos {
        grid-template-columns: 1fr;
        gap: 28px;
        max-width: 260px;
        margin-top: 60px;
        margin-bottom: 60px;
    }

    .ic-secao-tratamento {
        padding: 20px 0px
    }

    .ic-tratamento-card {
        width: 100%;
    }

    .ic-tratamento-card img {
        width: 100%;
        height: auto;
    }

    .ic-download p {
        margin-top: 20px;
        font-size: 19px;
    }

    .ic-download-botao {
        width: 100%;
        max-width: 310px;
        min-width: 0;
        min-height: 54px;
        font-size: 19px;
    }

    .ic-referencias {
        padding: 17px;
    }
}

/* =========================================================
   MOBILE PEQUENO
   ========================================================= */

@media (max-width: 480px) {
    .ic-marcas {
        margin-bottom: 30px;
    }

    .ic-marca-novartis {
        width: 138px;
    }

    .ic-marca-vms {
        width: 62px;
    }

    .ic-cabecalho h1 {
        font-size: 25px;
    }

    .ic-cabecalho p {
        font-size: 16px;
    }

    .ic-titulo-secao {
        font-size: 21px;
    }

    .ic-sintomas {
        gap: 48px;
    }

    .ic-sintoma {
        width: 100%;
        max-width: 255px;
        height: auto;
    }

    .ic-sintoma img {
        width: 100%;
        max-width: 180px;
        height: auto;
    }

    .ic-sintoma-terceiro {
        max-width: 238px;
        margin-top: 10px;
    }

    .ic-sintoma-terceiro img {
        max-width: 238px;
    }

    .ic-hospitalizacao p {
        font-size: 21px;
    }

    .ic-perfil-conteudo {
        align-items: flex-start;
        gap: 15px;
    }

    .ic-perfil-imagem {
        flex-basis: 95px;
        width: 95px;
        min-height: 120px;
    }

    .ic-perfil-imagem img {
        max-width: 95px;
        max-height: 120px;
    }

    .ic-perfil-texto h2 {
        font-size: 18px;
    }

    .ic-perfil-texto .ic-subtitulo {
        font-size: 15px;
    }

    .ic-perfil-texto li {
        font-size: 14px;
    }

    .ic-tratamentos {
        gap: 24px;
        max-width: 200px;
    }
}